AMNA NAWAZ: Welcome to the "News Hour."

The president's agenda and one of the largest bills in U.S. history is in the hands of the U.S. Senate.

Senators are in a daylong series of votes, what may be their last chance to change the bill, at stake, trillions in tax cuts, reshaping the country's immigration system, energy future and the future for Medicaid.

At this hour, it is unclear whether Republicans will have the votes.

Congressional correspondent Lisa Desjardins is here now with more on the bill's latest test in Congress.

So, Lisa, we know the Senate released its version of the bill near midnight on Friday.

I know you have been going through it.

What are some of the key changes they made we should know about?

LISA DESJARDINS: Right.

The Senate bill has fewer pages.

It's a little bit smaller than the House, but it is more aggressive on tax cuts and it is more expensive.

So, looking through it, first of all, the Senate would make permanent some business tax cuts that are temporary in the House bill.

In addition, on Medicaid, the Senate would actually increase one of the tax -- one of the Medicaid cuts in here, but delay it by a year.

Green energy, it adds a new solar and wind tax that those industries say would be very harmful, but that the senators behind it say would help.

The CBO has come to the conclusion that this bill would add $3.2 trillion to the debt over the next 10 years.

That is a major concern by a lot of Republicans.

They're talking about that number.

But, to be honest, this debate has centered around Medicaid, and particularly Democrats have been proposing amendment after amendment to try and reverse those cuts.

SEN. CHUCK SCHUMER (D-NY): My amendment simply says, if people's health care costs go up, the billionaire tax cuts vanish.

SEN. RON WYDEN (D-OR): It's the biggest Medicaid cut in history and represents the largest transfer of wealth in history.

SEN. LISA BLUNT ROCHESTER (D-DE): So, my colleagues, we have a choice.

Do we stand for billionaires or do we stand up for moms and babies?

LISA DESJARDINS: The Congressional Budget Office concluded that this bill would mean 12 million people would lose their insurance, but the other argument comes from Republicans.

They say that actually Medicaid is not sustainable as it stands right now and then what they're doing is closing some loopholes and ending some abuse.

SEN. JOHN THUNE (R-SD): Yes, there are some improvements and reforms to Medicaid to make it more efficient, to make sure that the people who are supposed to benefit from Medicaid do, and that it doesn't go to people who shouldn't benefit from Medicaid.

It's good for working families.

And it's been a long debate.

I know people are weary, but at the end of the day, we want to get this done.

LISA DESJARDINS: It has been a long debate.

This is a marathon this week, but it is not over yet.

We're waiting for some of those major amendment votes still.

AMNA NAWAZ: And, Lisa, as you and I speak here now, and we know things can change, but where does this bill stand?

Does it have the votes?

LISA DESJARDINS: This is very close, Amna.

By my count, they really are close to that three Republican vote limit that they can afford to lose on this bill.

So let's look specifically at what we know.

First of all, there are two no-votes, people who have said they are hard no's on this.

That's Rand Paul of Kentucky and Thom Tillis of North Carolina, who just announced this weekend he is retiring.

Now, in addition to that, I count at least seven votes to watch, in addition, who seem squeamish about the bill or have major problems with it, some from the right and some from the center.

One of those especially to watch is Lisa Murkowski of Alaska.

There was a provision in this bill, Amna, that was going to save Alaska from some of those Medicaid cuts, but it was dropped over the weekend by the Senate parliamentarian's ruling.

So it's not clear what will happen.

It's significant because outside groups are targeting Alaska, running ads like this one against Senator Dan Sullivan right now, saying that this will be bad for the state.

Now, he disagrees with that, but the point is that they really don't have the votes to spare.

And by my count, Amna, right now, this is headed through a tie vote in the Senate, and the vice president would break that tie.

The House, the future there much harder to see until we know what happens in the Senate.

AMNA NAWAZ: Lisa, I know you and our tireless politics team have been breaking out pieces of the bill to look at in a more in-depth way.

A major portion of this deals with the border.

What should we know about that?

LISA DESJARDINS: There is a great deal of spending, huge amounts of cash going to the border here.

Let's break it down, specifically this influx of cash.

First of all, there would be some $45 billion that they would invest in detention and deportation of migrants.

There would be $46.5 billion for a border wall system.

And there would be some $6 billion, look at this, this is proportional size-wise on this graphic, for surveillance, so much less for surveillance than for the wall system in here, and then $10 billion to some very general funds for states and for the Department of Homeland Security.

Amna, I read that bill and these $10 billion funds really don't have any specifics to them.

They are wide-ranging.

They can do whatever they want with them.

And for perspective, $10 billion, think of it this way, USAID, their annual budget for global health was $12 billion.

So this is what Republicans are doing here.

They're moving away from a global posture to an internal kind of blocking of protecting America that way.

AMNA NAWAZ: All right, Lisa Desjardins with the very latest for us from Capitol Hill.

Lisa, thank you.

LISA DESJARDINS: You're welcome.